Selenoproteins by Laurent Chavatte

Author:Laurent Chavatte
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

Application of the methodology reveals that SeP levels increase in serum and hepatic cytosolic extracts after Hg exposure and this effect is more pronounced with increasing selenite supplementation (Table 4). This fact reflects the synthesis of SeP from selenite and the antagonistic interaction between Hg and Se in mice serum and liver, since the Hg-SelP complex plays an important role as a vehicle for Hg detoxification [32]. In relation to this, decreased levels of Se-metabolites in serum and correlatively increased in liver cytosolic extracts are concordant with the requirement of selenite for SelP synthesis in the liver, which are then transferred to the bloodstream [33]. SelP levels are upregulated in the liver, which can explain the elevated concentration of this selenoprotein in this organ after Hg exposure period, and this fact is also more marked with increasing selenite supplementation, as in serum. In relation to this, decreased levels of SeAlb were observed in mouse serum when Hg is supplied alone and was accompanied by increased liver SeAlb concentration (Table 4), since this transport selenoprotein is transferred to the liver for the synthesis of SelP [33]. More pronounced effects were observed when Se was administered together with Hg at different increasing doses.3.Quantification of selenium species in maternal and umbilical cord serum by /SE-AF-HPLC -SUID -ICP-ORS-MS .

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